Oct
29
Viagra Drag

Viagra is a drug which is most famous and most used to treat disorders of erectile dysfunction, the inability to achieve or maintain a penile erection sufficient for satisfactory sexual activity.

Physiological process responsible for erection of the penis includes the release of a certain amount of nitrogen oxide (NO) in the corpus cavernosum during any sexual stimulus. Nitric oxide, in turn, activates an enzyme called guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood into the penis.

Sildenafil used in Viagra is an inhibitor of phosphodiesterase type 5, specific for cGMP (cyclic guanosine monophosphate) phosphodiesterase type 5 is localized mainly in the vascular smooth muscle of the corpora cavernosa of the penis and is the enzyme responsible for degradation of cGMP (cyclic guanosine monophosphate), therefore, inhibition of this enzyme by sildenafil leads to a higher concentration of cGMP (cyclic guanosine monophosphate), which translates into a more intense vasodilatation, and then in an erection more vigorous thanks to the greater contribution of blood to the penis. We can therefore say that sildenafil does not produce a direct relaxant effect on corpus cavernosum, but effectively increases the muscle relaxant effect of nitric oxide (NO) on the smooth muscle of the corpora cavernosa itself: When the NO / cGMP pathway is activated, as for example during sexual stimulation, inhibition of phosphodiesterase type 5 by sildenafil leads to a considerable increase in the levels of cGMP in the corpus cavernosum.

Erectile dysfunction can be conquered with the help of oral drugs as of 1998. Viagra being the first drug to be introduced to the market of impotence pills, there followed a n number of sildenafil citrate alterations and adjustments which are enhanced for the sake of their elevated efficiency, like Viagra Professional.

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We hope that shopping for Viagra will be simple and pleasurable. We love seeing out customers healthy and satisfied!